Documentos Frontiers 2011-02

Deaf plants, bleeding yeast and other surprising disease models from deeply conserved gene networksEdward M. MarcotteA single gene network accurately predicts phenotypic effects of gene perturbation in Caenorhabditis elegans | Systematic discovery of nonobvious human disease models through orthologous phenotypes
Genomic studies of adaptation in Drosophila and humansDmitri A. PetrovRelaxed Purifying Selection and Possibly High Rate of Adaptation in Primate Lineage-Specific Genes | Evidence that Adaptation in Drosophila Is Not Limited by Mutation at Single Sites
Mechanisms regulating leaf sizeDirk InzéIncreased Leaf Size: Different Means to an End | Survival and growth of Arabidopsis plants given limited water are not equal | Developmental Stage Specificity and the Role of Mitochondrial Metabolism in the Response of Arabidopsis Leaves to Prolonged Mild Osmotic Stress | Pause-and-stop – the effects of osmotic stress on cell proliferation during early leaf development in Arabidopsis and a role for ethylene signaling
Molecular arms races between viral and primate genomesHarmit S. MalikAltered Heterochromatin Binding by a Hybrid Sterility Protein in Drosophila Sibling Species | Protein kinase R reveals an evolutionary model for defeating viral mimicry | Paleovirology—Modern Consequences of Ancient Viruses
From genomes to diagnosis and treatment: a roadmap for personalized medicinePenelope E. BonnenA map of human genome variation from population-scale sequencing | Exome sequencing identifies MLL2 mutations as a cause of Kabuki syndrome | Targeted capture and massively parallel sequencing of 12 human exomes
Nuclear Organization and the Dynamics of Gene ExpressionDavid L. SpectorChromatin Dynamics | Direct visualization of the co-transcriptional assembly of a nuclear body by noncoding RNAs
The control of chromosome separation in mitosisDavid O. MorganHolt 2008.pdf | Holt 2008 Supp Info.pdf | Lyons 2011.pdf | Lyons 2011 Supp.pdf
Cloud Computing and the DNA Data RaceMichael SchatzCloudBurst: highly sensitive read mapping with MapReduce | Searching for SNPs with cloud computing | Cloud computing and the DNA data race | Quake: quality-aware detection and correction of sequencing errors
Dynamics of Chromatin RemodelingAshby J. MorrisonThe Biology of Chromatin Remodeling Complexes | INO80 and g-H2AX Interaction Links ATP-Dependent Chromatin Remodeling to DNA Damage Repair
Important lessons from complex genomesThomas R. Gingeras1787.full.pdf | IDR analysis 101 Measuring consistency between replicates in high-throughput experiments | The developmental transcriptome of Drosophila melanogaster
Systems biology meets cell biology: identifying the functions of host factors in virus replicationPeter D. NagyTomato bushy stunt virus Co-Opts the RNA-Binding Function of a Host Metabolic Enzyme for Viral Genomic RNA Synthesis | A Host Ca2+/Mn2+ Ion Pump Is a Factor in the Emergence of Viral RNA Recombinants | Yeast as a Model Host to Explore Plant Virus-Host Interactions | In vitro assembly of the Tomato bushy stunt virus replicase requires the host Heat shock protein 70 | Translation Elongation Factor 1A Facilitates the Assembly of the Tombusvirus Replicase and Stimulates Minus-Strand Synthesis
Addiction to Oncogenes--the Achilles Heal of CancerRaffaella SordellaTGF-β IL-6 axis mediates selective and adaptive mechanisms of resistance to molecular targeted therapy in lung cancer | science1.pdf | Mechanisms of Disease: oncogene addiction—a rationale for molecular targeting in cancer therapy